The difference between a base "set" and the box is that the box includes a base set plus a lot of extra inserts cards. The base set for series 1 is over 50 of Lovecraft's stories represented in cards (66 cards, total). The Series 2 base "set" will finish all of Lovecraft's stories with another 40 to 50 cards (those are getting painted now). The Series 1 box contains 24 wax packs. Those contain not only the full base set of Series 1, but also nearly all of the special inserts, including the six card Mythical Monster foil set, the three Sacred Souvenir cards, the Lovecraft Letters card, the Lovecraft credit card, the Cthulhu Necronomicard (a super cool lenticular card), both checklists, 2 promos, an original one-of-a-kind artist sketch card, and either an Abdul Alhazred prismatic card, or an actual printing plate used in the production of the series (each one unique). Also thrown in are two of six different HPL relics (an insanity certificate, a Miskatonic Diploma, Death Certificate, Innsmouth Burial Permit, Arkham Library Card, or Toe Tag)... not to mention all that devilishly delightful Ghoul Gum!