Alice Is Missing comes with 72 cards in the deck, which allow players to create new combinations of characters, motives, clues, suspects, and locations. The game also includes multiple endings, so you never know what direction the story is going to take.
The cards also ask very 'story forward' questions which put the details into the players hands.
Finally, playtesting has shown us that every group is different in how they tackle the game, so it's never the same experience twice. Though there are many different combinations of cards in the deck to improve variation from game to game, you could play with the exact same clue deck, and have a wildly different experience than you did last time.