It depends on how many people you play with. In a three player game, the most cards that will be played in order to find a winner would be thirteen. In a four player game it would be seventeen, five players = twenty one cards, and so on.
As mentioned in the last question, a game lasts longer with more players. So, even though a group of six would obviously burn through more cards in order to find a winner, that group would have at least twice as much gameplay time than a group of three.
Based on the tests we’ve done, you could expect somewhere between 4 and 16 hours of gameplay before you’ve covered every card at least once.