Yes, this is exactly the reason USB was chosen. The Laika API uses libftdi which in turn uses libusb:
"libFTDI works perfectly with Linux, Windows, MacOS X and BSD variants thanks to libusb"
Currently I have Laika working on Debian (Raspbian) and Windows. You can use a VCP too as the chip is an FTDI device, all that's needed is a standard FTDI driver. All the files and documentation for communicating will of course be made available for people to hack around with.
It would be great to get Laika working on a DD-WRT device and the Pogoplug. They've gone on my list.