What devices Epiphany controls can be broken down into two categories, simple IR drivers and servers which provide logic and two way communication.
Epiphany will ship with a pretty large library of IR codes, and its simple to learn in remotes that are not in the library.
Epiphany will also ship with a variety of servers - a list can be found at http://www.epiphanycontrol.com/?q=features-0. It is also pretty straight forward to write your own for devices we haven't covered yet, and we'll encourage people to share their work with each other.
We'll also be continuing to develop servers for new devices after we release the first version. These will be free to all existing customers. If you have an idea for a server thats not on our initial list, you can suggest it at https://epiphanycontrol.zendesk.com/home by clicking on "Server requests". The community can up-vote it there to help us decide which ones to do first.